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Beyer, Eric C.
One or more keywords matched the following properties of Beyer, Eric C.
PropertyValue
keywords Endothelial Cells
keywords Cell Biology
keywords Sickle Cell Disease
overview Professor of Pediatrics Section of Hematology/Oncology and Stem Cell Transplantation
overview Dr. Beyer is a physician scientist who practices pediatric hematology/oncology and has a broad background in basic laboratory and translational research. His laboratory has spent more nearly 30 years investigating intercellular communication (as mediated by the channels contained within gap junctions) and how its disruptions contribute to disease. These studies encompass basic investigations including identification and cloning of the subunit proteins, characterization of structure-function physiological relationships, determination of pathways of biosynthesis and degradation. Dr. Beyer's laboratory has also been pursuing translational examinations of the roles of these proteins in diseases including cataracts, deafness, arrhythmias, cancer, and premature labor. The group has spent many years studying the connexins expressed in the eye lens. They are elucidating the process of cataract development by studying mouse and cell culture models that mimic the pathologies seen in human families with connexin mutants and inherited cataracts. Dr. Beyer has investigated the roles of cardiac connexins in normal cardiac conduction and in the pathogenesis of arrhythmias. He is studying the roles of circulating extracellular vesicles in the vascular pathologies that underlie the crises of patients with sickle cell disease. He has mentored many students and post-doctoral fellows within his laboratory.
One or more keywords matched the following items that are connected to Beyer, Eric C.
Item TypeName
Concept Bone Marrow Cells
Concept Cell Communication
Concept Cell Line, Transformed
Concept Cell Membrane Permeability
Concept Cell Count
Concept Cell Differentiation
Concept Cell Movement
Concept Cell Nucleus
Concept Cell Membrane
Concept Cell Division
Concept Clone Cells
Concept Cell Cycle
Concept Cell Transformation, Neoplastic
Concept Cell Aggregation
Concept Cell Fusion
Concept Epithelial Cells
Concept Granulosa Cells
Concept HeLa Cells
Concept Receptors, Cell Surface
Concept CHO Cells
Concept Cell Culture Techniques
Concept Tumor Cells, Cultured
Concept Cell Proliferation
Concept COS Cells
Concept Cell Cycle Proteins
Concept Alveolar Epithelial Cells
Concept Cell Line, Tumor
Concept Anemia, Sickle Cell
Concept Cell Line
Concept Cell Survival
Concept Cells, Cultured
Academic Article Multiple connexins confer distinct regulatory and conductance properties of gap junctions in developing heart.
Academic Article Connexin43 mediates direct intercellular communication in human osteoblastic cell networks.
Academic Article Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes.
Academic Article Structural and molecular determinants of intercellular coupling in cardiac myocytes.
Academic Article Differential regulation of connexin43 and connexin37 in endothelial cells by cell density, growth, and TGF-beta1.
Academic Article Two-dimensional coupling by gap junctions in cultured gastric smooth muscle monolayers.
Academic Article Evidence for heteromeric gap junction channels formed from rat connexin43 and human connexin37.
Academic Article Cultured chicken embryo lens cells resemble differentiating fiber cells in vivo and contain two kinetic pools of connexin56.
Academic Article Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
Academic Article Cloning and functional expression of a novel gap junction channel from the retina of Danio aquipinnatus.
Academic Article Degradation of connexin43 gap junctions involves both the proteasome and the lysosome.
Academic Article Functional expression and biochemical characterization of an epitope-tagged connexin37.
Academic Article Regulation of connexin43 expression and function by prostaglandin E2 (PGE2) and parathyroid hormone (PTH) in osteoblastic cells.
Academic Article Functional expression and biophysical properties of polymorphic variants of the human gap junction protein connexin37.
Academic Article Heteromeric connexons formed by the lens connexins, connexin43 and connexin56.
Academic Article Modulation of intercellular communication by differential regulation and heteromeric mixing of co-expressed connexins.
Academic Article Connexin46 mutations linked to congenital cataract show loss of gap junction channel function.
Academic Article Gap junction messenger RNA expression by vascular wall cells.
Academic Article Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43.
Academic Article Characterization of gap junction channels in A7r5 vascular smooth muscle cells.
Academic Article Mouse connexin 45: genomic cloning and exon usage.
Academic Article Gap junction channels formed by coexpressed connexin40 and connexin43.
Academic Article PKC isoenzymes in the chicken lens and TPA-induced effects on intercellular communication.
Academic Article Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages.
Academic Article Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts.
Academic Article Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation.
Academic Article Cardiac gap junction channels show quantitative differences in selectivity.
Academic Article Peptide inhibitors of intercellular communication.
Academic Article In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B-cells.
Academic Article TGF-beta1 induces an accumulation of connexin43 in a lysosomal compartment in endothelial cells.
Academic Article Functional role of the carboxyl terminal domain of human connexin 50 in gap junctional channels.
Academic Article Heteromeric mixing of connexins: compatibility of partners and functional consequences.
Academic Article Loss of function and impaired degradation of a cataract-associated mutant connexin50.
Academic Article New developments in the gap junction field: report from the 2002 ASCB meeting.
Academic Article A carboxyl terminal domain of connexin43 is critical for gap junction plaque formation but not for homo- or hetero-oligomerization.
Academic Article Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5.
Academic Article Plasma membrane channels formed by connexins: their regulation and functions.
Academic Article Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis.
Academic Article N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26.
Academic Article A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts.
Academic Article Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis.
Academic Article Transgenic overexpression of connexin50 induces cataracts.
Academic Article The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum.
Academic Article Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells.
Academic Article The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation.
Academic Article A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract.
Academic Article The N terminus of connexin37 contains an alpha-helix that is required for channel function.
Academic Article Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50.
Academic Article An intact connexin N-terminus is required for function but not gap junction formation.
Academic Article Connexin40 and connexin43 determine gating properties of atrial gap junction channels.
Academic Article Different domains are critical for oligomerization compatibility of different connexins.
Academic Article Connexin43: a protein from rat heart homologous to a gap junction protein from liver.
Academic Article Inducible coexpression of connexin37 or connexin40 with connexin43 selectively affects intercellular molecular transfer.
Academic Article Cx30.2 can form heteromeric gap junction channels with other cardiac connexins.
Academic Article Selectivity of connexin-specific gap junctions does not correlate with channel conductance.
Academic Article Characterization of gap junctional communication-deficient mutants of a rat liver epithelial cell line.
Academic Article Modulation of connexin43 expression: effects on cellular coupling.
Academic Article A mutant connexin50 with enhanced hemichannel function leads to cell death.
Academic Article Autophagy: a pathway that contributes to connexin degradation.
Academic Article Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces.
Academic Article Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization.
Academic Article Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function.
Academic Article Characterization of the gap junction protein connexin56 in the chicken lens by immunofluorescence and immunoblotting.
Academic Article Expression of the gap junction protein connexin43 in embryonic chick lens: molecular cloning, ultrastructural localization, and post-translational phosphorylation.
Academic Article Selective dye and ionic permeability of gap junction channels formed by connexin45.
Academic Article Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells.
Academic Article Chick connexin-56, a novel lens gap junction protein. Molecular cloning and functional expression.
Academic Article Differential expression of two gap junction proteins in corneal epithelium.
Academic Article Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle.
Academic Article Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin40.
Academic Article Expression of multiple connexins in cultured neonatal rat ventricular myocytes.
Academic Article Distribution of gap junctions in dog and rat ventricle studied with a double-label technique.
Academic Article Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50.
Academic Article Lectins from chicken tissues are mitogenic for Thy-1 negative murine spleen cells.
Academic Article Connexin37 forms high conductance gap junction channels with subconductance state activity and selective dye and ionic permeabilities.
Academic Article The molecular basis of anisotropy: role of gap junctions.
Academic Article The gap junction protein connexin43 is degraded via the ubiquitin proteasome pathway.
Academic Article Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43.
Academic Article Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45.
Academic Article Characterization of the gap junction protein, connexin45.
Academic Article Cloning and expression of a Xenopus embryonic gap junction protein.
Academic Article Formation of gap junctions by expression of connexins in Xenopus oocyte pairs.
Academic Article Rat uterine myometrium contains the gap junction protein connexin45, which has a differing temporal expression pattern from connexin43.
Academic Article The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.
Academic Article Mechanisms for the coordination of intercellular calcium signaling in insulin-secreting cells.
Academic Article Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein.
Academic Article Connexin and gap junction degradation.
Academic Article Expression of different connexin genes in rat uterus during decidualization and at term.
Academic Article Tyrosine phosphorylation of a gap junction protein correlates with inhibition of cell-to-cell communication.
Academic Article Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels.
Academic Article Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins.
Academic Article An aberrant sequence in a connexin46 mutant underlies congenital cataracts.
Academic Article Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues.
Academic Article Electrical properties of mammalian lens epithelial gap junction channels.
Academic Article Developmentally regulated lectins from chick muscle, brain, and liver have similar chemical and immunological properties.
Academic Article Change of isoforms' spectra of alpha-L-fucosidase from human skin fibroblasts in intracellular storage of nonhydrolyzable substances.
Academic Article Quantitation of two endogenous lactose-inhibitable lectins in embryonic and adult chicken tissues.
Academic Article Chicken tissue binding sites for a purified chicken lectin.
Academic Article c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.
Academic Article An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract.
Academic Article A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor.
Academic Article Atrial fibrillation-associated connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties.
Academic Article Roles and regulation of lens epithelial cell connexins.
Academic Article Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated.
Academic Article Gap junction protein connexin43 exacerbates lung vascular permeability.
Academic Article Connexin50D47A decreases levels of fiber cell connexins and impairs lens fiber cell differentiation.
Academic Article Connexin40 abnormalities and atrial fibrillation in the human heart.
Academic Article Muscle development in vitro following X irradiation.
Academic Article The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating.
Academic Article The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses.
Academic Article Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins.
Academic Article Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings.
Academic Article Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice.
Academic Article Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses.
Academic Article Characterization of a variant of gap junction protein a8 identified in a family with hereditary cataract.
Academic Article CHOP is dispensable for lens transparency in wild-type and connexin50 mutant mice.
Academic Article p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency.
Academic Article Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells.
Academic Article Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease.
Academic Article Gap Junctions between Endothelial Cells Are Disrupted by Circulating Extracellular Vesicles from Sickle Cell Patients with Acute Chest Syndrome.
Academic Article Insights image for "Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells".
Academic Article Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation.
Academic Article Circulating Small Extracellular Vesicles May Contribute to Vaso-Occlusive Crises in Sickle Cell Disease.
Academic Article Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice.
Academic Article Connexin Mutants Cause Cataracts Through Deposition of Apatite.
Academic Article Loss of fiber cell communication may contribute to the development of cataracts of many different etiologies.
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